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Tyrosinase, Mushroom

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Tyrosinase (16) Apoptosis (1) Autophagy (1) Fungal (2) HSV (1) Interleukin Related (2) NF-κB (1) PPAR (1) Sirtuin (1) TNF Receptor (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Endocrinology (1) Infection (4) Inflammation/Immunology (4) Metabolic Disease (2)

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Targets Recommended: Tyrosinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125860

**Tyrosinase, Mushroom** Polyphenol oxidase	Tyrosinase	Metabolic Disease
Tyrosinase (EC 1.14.18.1) (Polyphenol oxidase) is a rate-limiting enzyme that controls the production of melanin and is encoded by TYR gene. Tyrosinase is mainly found in melanosomes synthesized by skin melanocytes .

HY-N3266

Methyl rosmarinate	Tyrosinase	Cancer
Methyl rosmarinate is a noncompetitive *tyrosinase* inhibitor which is isolated from Rabdosia serra, with an IC₅₀ of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase .

HY-161289

Tyrosinase-IN-24

Tyrosinase Cancer

Tyrosinase-IN-24 (compound 3b) is a tyrosinase inhibitor with inhibitory activity against mushroom tyrosinase .

Tyrosinase-IN-24	Tyrosinase	Cancer
Tyrosinase-IN-24 (compound 3b) is a tyrosinase inhibitor with inhibitory activity against mushroom tyrosinase .

HY-122933

Kurarinol	Tyrosinase Apoptosis	Cardiovascular Disease Cancer
Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive *tyrosinase* inhibitor, with IC₅₀ of 0.1 μM for mushroom tyrosinase .

HY-N10287

Leptosin D

Tyrosinase Infection

Leptosin D, a thiodiketopiperazine alkaloid, is a mushroom tyrosinase inhibitor, with an IC₅₀ of 28.4 μM .
HY-N10286

Chetoseminudin B

Tyrosinase Others

Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC₅₀ of 31.7 μM .
HY-131327

Azo-resveratrol

Tyrosinase Cancer

Azo-resveratrol, an Azo compound, inhibits Mushroom tyrosinase (IC₅₀=36.28 μM).

Leptosin D	Tyrosinase	Infection
Leptosin D, a thiodiketopiperazine alkaloid, is a **mushroom tyrosinase inhibitor, with an IC₅₀** of 28.4 μM .

Chetoseminudin B	Tyrosinase	Others
Chetoseminudin B possesses **mushroom tyrosinase inhibitory activity with IC₅₀** of 31.7 μM .

Azo-resveratrol	Tyrosinase	Cancer
Azo-resveratrol, an Azo compound, inhibits **Mushroom tyrosinase (IC₅₀**=36.28 μM).

HY-N10219

Dihydroaltenuene B	Tyrosinase Fungal	Infection
Dihydroaltenuene B is a potent **mushroom tyrosinase inhibitor with an IC₅₀** of 38.33 µM. Dihydroaltenuene B shows the hydrogen bonding interactions between the 3-OH and 4’-OH and the His244, Met280 and Gly281 residues of tyrosinase .

HY-117761

MHY908

PPAR Metabolic Disease Cancer

MHY908 is a potent dual agonist of PPARα and PPARγ . MHY908 also inhibits melanogenesis through inhibition of mushroom tyrosinase activity .

MHY908	PPAR	Metabolic Disease Cancer
MHY908 is a potent dual agonist of PPARα and PPARγ . MHY908 also inhibits melanogenesis through inhibition of mushroom tyrosinase activity .

HY-N2101

Benzoyloxypaeoniflorin	Tyrosinase NF-κB	Inflammation/Immunology
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a *tyrosinase* inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation .

HY-N10285

Phaeosphaone D	Tyrosinase	Infection
Phaeosphaone D is a thiodiketopiperazine alkaloid compound isolated from Phaeosphaeria fuckelii, an endophytic fungus. Phaeosphaone D displays mushroom tyrosinase inhibitory activity with an IC₅₀ value of 33.2 μM .

HY-P0096

Decapeptide-12	Tyrosinase Sirtuin	Inflammation/Immunology Endocrinology
Decapeptide-12, a small oligopeptide, is a *tyrosinase* inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of **mushroom tyrosinase (IC₅₀**: 40 µM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

HY-W013571

4-Isopropylbenzoic acid	Fungal	Infection
4-Isopropylbenzoic acid, an aromatic monoterpenoid, is isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid exhibits antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive inhibitor of **mushroom tyrosinase** .

HY-N1430

Oxyresveratrol trans-Oxyresveratrol	Tyrosinase HSV Autophagy	Others
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive *tyrosinase* inhibitor with an IC₅₀ value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .

HY-N3773

Dodoviscin A	Tyrosinase	Cancer
Dodoviscin A is a pigmentation-altering agent, which can be isolated from the aerial parts of Dodonaea viscosa. Dodoviscin A inhibits melanin production in B16-F10 melanoma cells. Dodoviscin A suppresses **mushroom tyrosinase** activity, and tyrosinase activity induced by 3-isobutyl-1-methylxanthine. Dodoviscin A also inhibits the phorphosylation of cAMP response element binding protein, induced by 3-isobutyl-1-methylxanthine and forskolin .

HY-N7135

Tropolone	Tyrosinase	Others
Tropolone is a Tropone derivative with a hydroxyl group at the 2-position, and is the precursor of many Azulene derivatives, such as 2-methylazulene-1-carboxylate. Tropolone is a potent **mushroom tyrosinase inhibitor with an IC₅₀** of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU ²⁺ Reversal .

HY-N0619

Mulberroside A 2 Publications Verification	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom *tyrosinase* with an IC₅₀ of 53.6 μM .

HY-N0619A

cis-Mulberroside A Mulberroside D	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom *tyrosinase* with an IC₅₀ of 53.6 μM .

Decapeptide-12	Tyrosinase Sirtuin	Inflammation/Immunology Endocrinology
Decapeptide-12, a small oligopeptide, is a *tyrosinase* inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of **mushroom tyrosinase (IC₅₀**: 40 µM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

Methyl rosmarinate	Classification of Application Fields Simple Phenylpropanols Labiatae Source classification Phenols Polyphenols Phenylpropanoids Plants Baccharis darwinii Hook. & Arn. Disease Research Fields Cancer	Tyrosinase
Methyl rosmarinate is a noncompetitive *tyrosinase* inhibitor which is isolated from Rabdosia serra, with an IC₅₀ of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase .

Kurarinol	Cardiovascular Disease Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields	Tyrosinase Apoptosis
Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive *tyrosinase* inhibitor, with IC₅₀ of 0.1 μM for mushroom tyrosinase .

Leptosin D	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids	Tyrosinase
Leptosin D, a thiodiketopiperazine alkaloid, is a **mushroom tyrosinase inhibitor, with an IC₅₀** of 28.4 μM .

Chetoseminudin B	Alkaloids Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields Indole Alkaloids	Tyrosinase
Chetoseminudin B possesses **mushroom tyrosinase inhibitory activity with IC₅₀** of 31.7 μM .

Dihydroaltenuene B	Infection Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields	Tyrosinase Fungal
Dihydroaltenuene B is a potent **mushroom tyrosinase inhibitor with an IC₅₀** of 38.33 µM. Dihydroaltenuene B shows the hydrogen bonding interactions between the 3-OH and 4’-OH and the His244, Met280 and Gly281 residues of tyrosinase .

Benzoyloxypaeoniflorin	Other Monoterpenes Monophenols Classification of Application Fields Paeonia lactiflora Pall. Terpenoids Source classification Phenols Plants Paeoniaceae Inflammation/Immunology Disease Research Fields	Tyrosinase NF-κB
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a *tyrosinase* inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation .

Phaeosphaone D	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids	Tyrosinase
Phaeosphaone D is a thiodiketopiperazine alkaloid compound isolated from Phaeosphaeria fuckelii, an endophytic fungus. Phaeosphaone D displays mushroom tyrosinase inhibitory activity with an IC₅₀ value of 33.2 μM .

4-Isopropylbenzoic acid	Infection other families Classification of Application Fields Bridelia retusa Ketones, Aldehydes, Acids Source classification Euphorbiaceae Plants Disease Research Fields	Fungal
4-Isopropylbenzoic acid, an aromatic monoterpenoid, is isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid exhibits antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive inhibitor of **mushroom tyrosinase** .

Oxyresveratrol trans-Oxyresveratrol	Structural Classification other families Stilbenes Classification of Application Fields Anti-aging Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Tyrosinase HSV Autophagy
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive *tyrosinase* inhibitor with an IC₅₀ value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .

Dodoviscin A	Structural Classification Flavonoids Flavones Source classification Dodonaea viscosa (L.) Jacq. Sapindaceae Plants	Tyrosinase
Dodoviscin A is a pigmentation-altering agent, which can be isolated from the aerial parts of Dodonaea viscosa. Dodoviscin A inhibits melanin production in B16-F10 melanoma cells. Dodoviscin A suppresses **mushroom tyrosinase** activity, and tyrosinase activity induced by 3-isobutyl-1-methylxanthine. Dodoviscin A also inhibits the phorphosylation of cAMP response element binding protein, induced by 3-isobutyl-1-methylxanthine and forskolin .

Tropolone	Olax imbricata Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Olacaceae Other Diseases Plants Disease Research Fields	Tyrosinase
Tropolone is a Tropone derivative with a hydroxyl group at the 2-position, and is the precursor of many Azulene derivatives, such as 2-methylazulene-1-carboxylate. Tropolone is a potent **mushroom tyrosinase inhibitor with an IC₅₀** of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU ²⁺ Reversal .

Mulberroside A 2 Publications Verification	Structural Classification Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Morus alba L. Plants Moraceae Inflammation/Immunology Disease Research Fields	TNF Receptor Interleukin Related Tyrosinase
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom *tyrosinase* with an IC₅₀ of 53.6 μM .

cis-Mulberroside A Mulberroside D	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn.	TNF Receptor Interleukin Related Tyrosinase
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom *tyrosinase* with an IC₅₀ of 53.6 μM .

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Tyrosinase, Mushroom

Inhibitors & Agonists

Peptides

NaturalProducts

Natural
Products